Registration Dossier

Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Allergien gegenüber aromatischen Amino- und Nitroverbindungen.
Author:
Schulz, K.H.
Year:
1962
Bibliographic source:
Berufsdermatosen 10, 69-91

Materials and methods

Type of sensitisation studied:
skin
Study type:
study with volunteers
Principles of method if other than guideline:
Epicutaneous test with patients suffering from dermatitis.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): nitrobenzene
- Analytical purity: no data

Method

Type of population:
general
Route of administration:
dermal

Results and discussion

Results of examinations:
Epicutaneous tests for the evaluation of nitrobenzene (applied concentration 1%) as a potential sensitizer in 3
persons were negative (no details specified).
3/15 persons, sensitized by p-phenyldiamine or azo-dyes showed a weak reaction to nitrobenzene.

Applicant's summary and conclusion