Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Allergien gegenüber aromatischen Amino- und Nitroverbindungen.
Author:
Schulz, K.H.
Year:
1962
Bibliographic source:
Berufsdermatosen 10, 69-91

Materials and methods

Type of sensitisation studied:
skin
Study type:
study with volunteers
Principles of method if other than guideline:
Epicutaneous test with patients suffering from dermatitis.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Nitrobenzene
EC Number:
202-716-0
EC Name:
Nitrobenzene
Cas Number:
98-95-3
Molecular formula:
C6H5NO2
IUPAC Name:
nitrobenzene
Details on test material:
- Name of test material (as cited in study report): nitrobenzene
- Analytical purity: no data

Method

Type of population:
general
Route of administration:
dermal

Results and discussion

Results of examinations:
Epicutaneous tests for the evaluation of nitrobenzene (applied concentration 1%) as a potential sensitizer in 3
persons were negative (no details specified).
3/15 persons, sensitized by p-phenyldiamine or azo-dyes showed a weak reaction to nitrobenzene.

Applicant's summary and conclusion