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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Excretion of p-Nitrophenol and p-Aminophenol in the urine of a patient exposed to nitrobenzene.
Author:
Ikeda, M. and Kitta, A.
Year:
1964
Bibliographic source:
Brit. J. Industr. Med. 21, 210-213

Materials and methods

Objective of study:
metabolism
Principles of method if other than guideline:
Five adult Wistar rats were exposed to nitrobenzene vapour (0.13 mg/L) for 8 hours. Urinary levels of p-nitrophenol and p-aminophenol were determined using the method of Brodie and Axelrod (1948) after 24, 48 and 72 hours.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): nitrobenzene
- Analytical purity: no data
Radiolabelling:
no

Test animals

Species:
rat
Strain:
Wistar
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Vehicle:
not specified
Duration and frequency of treatment / exposure:
single treatment for 8 hours
Doses / concentrations
Remarks:
Doses / Concentrations:
0.13 mg/L (25 ppm)
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
The metabolites p-nitrophenol and p-aminophenol of nitrobenzene were identified and quantified.

Any other information on results incl. tables

Urinary levels of p-nitrophenol (p-aminophenol) (µmoles/day and rat) were ca. 1800 (1200) after 24 hours, ca. 500 (both) after 48 hours and 0 (both) after 72 hours.

Applicant's summary and conclusion