Registration Dossier

Toxicological information

Repeated dose toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
repeated dose toxicity: dermal
Remarks:
other: range finding study
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Original reference not yet available

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1983
Report Date:
1983
Reference Type:
secondary source
Title:
European Union Risk Assessment Report (Draft), NITROBENZENE CAS No: 98-95-3
Author:
European Chemicals Bureau
Year:
2007

Materials and methods

Principles of method if other than guideline:
no data given in European Union Risk Assessment Report (Draft) (2007)
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): nitrobenzene
- Analytical purity: no data

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male/female

Administration / exposure

Type of coverage:
other: skin painting
Vehicle:
not specified
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
2 weeks
Frequency of treatment:
single
Doses / concentrations
Remarks:
Doses / Concentrations:
200 to 3200 mg/kg bw/d
Basis:

No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

All rats at the 1600 and 3200 mg/kg bw/d doses died or were sacrificed moribund prior to the end of treatment. Treated animals were inactive, ataxic, prostrate and dyspnoeic. Histologically, rats showed changes in the brain, liver, spleen and testes. Reticulocyte counts and methaemoglobin levels were increased (all dosage groups); haemoglobin and red blood cells were decreased. No quantitative details on blood parameters included in the report.

Applicant's summary and conclusion