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EC number: 701-197-2
CAS number: -
Structurally similar substance Polyglycidyl ether of substituted glycerine (EPON 562) showed carcinogenic activity in several animal studies.
to the profiling results of the OECD QSAR Toolbox (v3.1), the epoxides
are binders to DNA via SN2 mechanism. They may react directly
with the nucleophilic centres of the DNA (nitrogen atoms in guanine,
adenine and cytosine) forming highly mutagenic sites leading to
mutations. Therefore, the epoxides are allocated as genotoxic
carcinogens which attack DNA fragments directly without enzymatic
activation. According to the endpoint specific profilers, the target
chemical possess mutagenic and carcinogenic activity. Its nearest
analogue polyglycidyl ether of substituted glycerine possesses
carcinogenic activity in rats and in mice (Hine et al., 1981). There are
numerous studies available for a variety of structurally similar epoxy
compounds. The chemicals containing the same glycidyloxy moieties in
their structures, and having physico-chemical properties such as water
solubility, logPow and vapour pressure are similar to those of the
target chemical. Those chemicals caused tumors at many different tissues
in different animal species (please refer to read-across statement
attached to this IUCLID file). On the other hand, there was no
indication of tumorigenic potential of the target substance in workers
who were exposed to the finishing agent containing glycerol polyglycidyl
ether during a lot of years (Lanes et al., 1994; Watkins et al., 2001).
For most causes of death, mortality rates in the cohort were similar to
mortality rates in the US population (Lanes et al., 1994). In the follow
up study, there were no significant differences in the mortality rates
between race and gender groups within the same cohort, compiled by Lanes
et al. in 1994 (Watkins et al., 2001). All causes of death and all
cancer causes of death were below unity on both national and local
(country in which plant is located) standards (Watkins et al., 1994).
For white males, there were no statistically significant increases for
any cause of death with the exception of benign neoplasms. However,
these findings only do not represent a clear evidence of carcinogenic
effect of glycerol polyglycidyl ether in humans. Furthermore, the major
limitation of the human studies is the lack of work history data
allowing classification of employees to the plant operation with
exposure of interest. Based on these data, no carcinogenic potential
could be attributed for the target substance.
according to the European Regulation (EC) No. 1272/2008, classification
and labelling is not warranted for this endpoint.
The "Patty´s Industrial Hygiene and
Toxicology" contains information about Polyglycidyl ether of
substituted glycerine (EPON 562) (Hine et al., 1981). There is a study
mentioned, in which the skin of mice was painted with the material from
once weekly to trice weekly over a period of a year and carcinomas were
produced on the skin of mice. However, no tumours were produced in
rabbits treated dermally with the substance of interest. In addition, a
study is mentioned, where rats were treated subcutaneously with the
material and sarcomas were produced. Moreover,
a study is mentioned, where the test material was fed in the diet (0.2
%) to A strain of mice with spontaneous pulmonary adenomas, there was no
effect on the incidence of occurrence.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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