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EC number: 701-197-2
CAS number: -
order to assess the toxicological behaviour of1,2,3-propanetriol,
the available physico-chemical and toxicological data have been
evaluated. The substance is expected to be well absorbed after oral
exposure, based on its water solubility, its logPow of -1.78 / -1.94 and
acute toxicity data via oral administration. Concerning the absorption
after exposure via inhalation, as the chemical has low vapour pressure
and is highly hydrophilic, it is clear, that the substance is poorly
available for inhalation and will not be absorbed significantly.1,2,3-propanetriol,
also not expected to be absorbed following dermal exposure into the
stratum corneum and into the epidermis, due to its molecular weight and
its logPow. Concerning its distribution in the body1,2,3-propanetriol,
expected to be distributed mainly in the intravasal compartment, due to
its logPow. The substance does not indicate a significant potential for
expected to be metabolised mainly via epoxide hydrolases (esterases),
cytochrome P450s and alcohol dehydrogenase and subsequently eliminated
unchanged or as metabolites via the urine.
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