Registration Dossier
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EC number: 701-197-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to reproduction
Administrative data
- Endpoint:
- one-generation reproductive toxicity
- Remarks:
- based on test type (migrated information)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: OECD Toolbox 3.0, is a harmonized system for OSAR application and grouping chemicals into categories, which OECD principles are met
Data source
Reference
- Reference Type:
- other: prediction by the OECD QSAR Toolbox
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 415 [One-Generation Reproduction Toxicity Study (before 9 October 2017)]
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1-chloro-2,3-epoxypropane
- EC Number:
- 203-439-8
- EC Name:
- 1-chloro-2,3-epoxypropane
- Cas Number:
- 106-89-8
- Molecular formula:
- C3H5ClO
- IUPAC Name:
- 2-(chloromethyl)oxirane
- Test material form:
- other: liquid
- Details on test material:
- Target substance:
Mixture of 1,2,3-Propanetriol, polymer with 2-(chloromethyl)oxirane (CAS 25038-044-4) and 1,2,3-Propanetriol, glycidyl ethers:
SMILES:C(O)(CO)CO_C1(CCl)CO1_C1(COC(COCC2CO2)COCC2CO2)CO1
Read-across substances:
Epichlorohydrin (CAS 106-89-8): C1(CCl)CO1
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
- Dose descriptor:
- LOAEL
- Effect level:
- 3.3 mg/kg bw/day (nominal)
- Sex:
- male/female
- Remarks on result:
- other: no further information available
Results: F1 generation
Effect levels (F1)
- Remarks on result:
- other: not predicted with Toolbox
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
The prediction was based on dataset comprised from the following descriptors: LOAEL
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression: Result: Out of Domain
("a" and ("b" and "c" ) )
Domain logical expression index: "a"
Referential boundary: The target chemical should be classified as Epoxides by US-EPA New Chemical Categories
Domain logical expression index: "b"
Parametric boundary:The target chemical should have a value of log Kow which is >= 0.626
Domain logical expression index: "c"
Parametric boundary:The target chemical should have a value of log Kow which is <= 0.626
Applicant's summary and conclusion
- Conclusions:
- Epychlorohydrin caused reduced male fertility with histopathological changes in the testis and epididymidis and therefore reproductive adverse effects of the target substance cannot be ruled out. However, the read-across substance epichlorohydrin is not classified officially as toxic to reproduction therefore no decision on classification and labelling for reproductive toxicity can be assigned to the target chemical GE-100 based on this data.
- Executive summary:
The target chemical was profiled as "Epoxides" by the "US EPA New Chemical Categories". Common properties of epoxides are high reactivity, cytotoxicity, and high probability of mutagenic potential and/or carcinogenicity. Therefore chemicals with the same profiling result have been retrieved from the database. The chemicals containing other chemical elements in their structure and/or other organic functional groups were considered dissimilar to the target chemical and have been removed from the domain.
The target chemical is obtained by the reaction of epichlorohydrin with glycerol. Therefore, epichlorohydrin is considered to be a suitable candidate for read-across. Moreover, its profiling results regarding binding to proteins and to DNA (properties which are likely responsible for reproductive toxicity) are similar to those of the target.
Epichlorohydrin caused reduced male fertility and an increase in the incidence of histopathological changes of the testis and epididymidis and therefore reproductive adverse effects of the target chemical cannot be ruled out as well.
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