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EC number: 701-197-2
CAS number: -
The test substance was administered via oral
gavage to groups of five male and/or female fasted Sprague-Dawley rats.
In the first instance, the test substance was administered undiluted, at
the dose of 2000 mg/kg (dose volume 1.67 ml/kg, taking into
consideration that its specific gravity was 1.2. As 50 % mortality
occurred in this limit test, the test substance was then prepared in
corn oil and administered to other animals at lower doses (1415 mg/kg
and 1000 mg/kg in corn oil (dose volume 10 ml/kg) to 5 females each).
Clinical signs, mortality and body weight gain were checked for a period
of up to 14 days following the single administration of the test
substance. All animals were subjected to necropsy. At the 2000 mg/kg
dose-level 3/5 males and 2/5 females died between days 1 and 4.
Hypoactivity or sedation and piloerection were observed in all animals
from day 1 up to day 3 at the latest, coma was observed prior to death
in one female. Recovery was complete in the surviving animals on day 2.
At the 1415 mg/kg dose-level, no mortality was observed. Hypoactivity
and piloerection were noted in 3/5 females on day 1. At the 1000 mg/kg
dose-level, no mortality was observed. Hypoactivity was noted in all
females on day 1. The body weight gain of the surviving animals was not
affected by treatment with the test substance. No apparent abnormalities
were observed in all the animals at necropsy. In conclusion and under
the experimental conditions, the oral LD50 of the test substance is near
2000 mg/kg. In accordance with ethic and scientific recommendations
concerning the LD50, a more precise determination was not conducted.
According to the classification criteria laid down in Commission
Directive 93/21/EEC, concerning the potential toxicity by the oral
route, the test substance should be assigned the symbol Xn, the
indication of danger "Harmful" an the risk phrase R 22 " Harmful if
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