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EC number: 701-197-2
CAS number: -
order to cross the skin, a compound must first penetrate into the
stratum corneum and may subsequently reach the epidermis, the dermis and
the vascular network. The stratum corneum provides its greatest barrier
function against hydrophilic compounds, whereas the epidermis is most
resistant to penetration by highly lipophilic compounds. Substances with
a molecular weight below 100 are favourable for penetration of the skin
and substances above 500 are normally not able to penetrate. The
substance must be sufficiently soluble in water to partition from the
stratum corneum into the epidermis. Therefore if the water solubility is
below 1 mg/L, dermal uptake is likely to be low. Additionally LogPow
values between 1 and 4 favour dermal absorption (values between 2 and 3
are optimal; TGD, Part I, Appendix VI). Above 4, the rate of penetration
may be limited by the rate of transfer between the stratum corneum and
the epidermis, but uptake into the stratum corneum will be high. Above
6, the rate of transfer between the stratum corneum and the epidermis
will be slow and will limit absorption across the skin. Uptake into the
stratum corneum itself may be slow. Moreover substances with vapour
pressures below 100 Pa are likely to be well absorbed and the amount
absorbed dermally is most likely more than 10% of the amount that would
be absorbed by inhalation. If the substance is a skin irritant or
corrosive, damage to the skin surface may enhance penetration. During
the whole absorption process into the skin, the compound can be subject
the molecular weight is above 100 and below 500, which indicates already
a lower potential to penetrate the skin. This is accompanied by a high
hydrophilicity (logPow of -1.78/-1.94) of the substance and the stratum
corneum is very resistant against penetration by highly hydrophilic
substances. However, the negligible amount of 1,2,3-propanetriol,
is absorbed following dermal exposure into the stratum corneum is
however likely to be also transferred into the epidermis. As the
substance is irritating to skin and eyes, this might enhance dermal
absorption. However, the systemic toxicity of 1,2,3-propanetriol,
glycidyl ethers via
the skin has been shown to be very low (acute dermal toxicity, LD50
value of greater than 2000 mg/kg bw for rats, Manciaux, 1998).
conclusion, the evaluation of all the available indicators and the
results of toxicity studies allow the allocation of the chemical in
question into the group of chemicals with a very low dermal absorption.
In detail, despite its molecular weight, the use of a factor of 10 % for
the estimation of dermal uptake for 1,2,3-propanetriol, glycidyl ethers
is justified, which is based on the water solubility, the logPow and the
results for acute toxicity (please
refer to the section "DNEL calculation").
order to assess the toxicological behaviour of1,2,3-propanetriol,
the available physico-chemical and toxicological data have been
evaluated. The substance is expected to be well absorbed after oral
exposure, based on its water solubility, its logPow of -1.78 / -1.94 and
acute toxicity data via oral administration. Concerning the absorption
after exposure via inhalation, as the chemical has low vapour pressure
and is highly hydrophilic, it is clear, that the substance is poorly
available for inhalation and will not be absorbed significantly.1,2,3-propanetriol,
also not expected to be absorbed following dermal exposure into the
stratum corneum and into the epidermis, due to its molecular weight and
its logPow. Concerning its distribution in the body1,2,3-propanetriol,
expected to be distributed mainly in the intravasal compartment, due to
its logPow. The substance does not indicate a significant potential for
expected to be metabolised mainly via epoxide hydrolases (esterases),
cytochrome P450s and alcohol dehydrogenase and subsequently eliminated
unchanged or as metabolites via the urine.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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