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Short-term toxicity to aquatic invertebrates

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Description of key information

Calculation with ECOSAR v0.99g (EPIWIN software by US-EPA): 
Main component with chlorine: EC50(48h): 4.38 mg/L
Main component without chlorine: EC50(48h): 4.06 mg/L

Key value for chemical safety assessment

Additional information

The acute toxicity to Daphnia magna of the test substance was predicted by the computer program ECOSAR v0.99g (EPIWIN software) by US-EPA (Chemservice S.A., 2012; prediction performed by data owner).An extensive set of structure – activity relationships (SARs) is utilized by the computer program, to predict the acute and chronic toxicity for three trophic levels for aquatic species, based on the neutral organics SAR (Baseline Toxicity).The mode of toxic action for most neutral organic chemicals is narcosis, and many chemical classes present toxicity to organisms via narcosis (i.e. ethers, alcohols, ketones). However, some organic chemical classes have been identified as having a more specific mode of toxicity. These are typically organics that are reactive and ionizable and that exhibit excess toxicity in addition to narcosis (i.e. acrylates, epoxides, anilines). For the test substance,“diepoxides” were detected as Ecosar-class.The short-term results (EC50) for the substance including chlorine concerning daphnids (48h) was given as 4.38 mg/L. If the compound contains no chlorine, the predicted result differ a little; the EC50(48h) is 4.06 mg/L. Therefore, it can be assumed that the toxicity is not significantly affected by a chlorine molecule.

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