Registration Dossier
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EC number: 701-197-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well-documented publication, which meets basic scientific principles
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- The Toxicology of Epoxy Resins
- Author:
- Hine, C.H., Kodama, J.K., Anderson, H.H., Simonson, D.W., Wellington, J.S.
- Year:
- 1 958
- Bibliographic source:
- AMA archive s of industrial health / American Medical Association, 17, p. 129-144
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test material was applied on the clipped backs of Albino rabbits and held in contact under semiocclusive conditions during 24 hours. The readings were made directly and after 48 hours after the pathch removal.
- GLP compliance:
- no
Test material
- Reference substance name:
- Polyglycidyl Ether of Substituted Glycerin (EPON 562)
- IUPAC Name:
- Polyglycidyl Ether of Substituted Glycerin (EPON 562)
- Details on test material:
- - Name of test material (as cited in study report): EPON 562
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.0 - 3.2 kg
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipped over the back and flanks, and four areas of the back designated for the test, two intact and two scarified with wire mesh
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- no details given
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 72 hours
- Number of animals:
- no data
- Details on study design:
- Albino rabbits were clipped over the back and flanks, and four areas of the back designated for the test, two intact and two scarified with wire mesh. The animals were immobilized in a multiple rabbit holder (Laug, 1944), and patches of gauze were secured over the areas with adhesive tape. The compounds were introduced under the patches, and the entire trunk of the rabbits enveloped in rubber dam. After 24 hours the rabbits were released, the resins removed, and a first reading made. After 72 hours a second reading was made.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 and 72 h
- Score:
- 5
- Reversibility:
- no data
- Remarks on result:
- other: moderately irritating
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- This well-documented publication gives a detailed information about the experiments conducted and meets basic scientific principles. Therefore it is considered to be of the high quality (reliability Klimisch 2). The validity criteria of the test system are fulfilled. EPON 562 was moderately irritating, with a score of five.
- Executive summary:
The skin irritation potential of Polyglycidyl Ether of Substituted Glycerin (EPON 562) was investigated by Hine et al.(1958). The test material was administered semiocclusively to rabbits (male Albino). The rabbits were clipped over the back and flanks, and four areas of the back designated for the test, two intact and two scarified with wire mesh. The animals were immobilized in a multiple rabbit holder, and patches of gauze were secured over the areas with adhesive tape. The compound was introduced under the patches, and the entire trunk of the rabbits enveloped in rubber dam. After 24 hours the rabbits were released, the resin removed, and a first reading made. After 72 hours a second reading was made. EPON 562 was moderately irritating, with a score of 5.
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