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EC number: 701-197-2
CAS number: -
prediction was based on dataset comprised from the following
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
and "c" )
logical expression index: "a"
target chemical should be classified as Epoxides by US-EPA New Chemical
logical expression index: "b"
target chemical should have a value of log Kow which is >= -1.1
logical expression index: "c"
target chemical should have a value of log Kow which is <= 2.37
The target chemical was profiled as
"Epoxides" by the "US EPA New Chemical Categories". Common properties of
epoxides are high reactivity, cytotoxicity, and high probability of
mutagenic potential and/or carcinogenicity. Therefore chemicals with the
same profiling result have been retrieved from the database. The
chemicals containing other chemical elements in their structure and/or
other organic functional groups were considered dissimilar to the target
chemical and have been removed from the domain.
The target chemical is obtained by the
reaction of epichlorohydrin with glycerol. Therefore, epichlorohydrin is
considered to be a suitable candidate for read-across. Glycidol is the
simplest representative of glycidyl ethers category (HPV, Epoxy Resin
Systems Task Group (ERSTG), 2001). 7-oxabicyclo-hept-3-ylmethyl
7-oxabicyclo-heptane-3-carboxylate is more lipophilic representative of
glycidyl ethers category. Moreover, the profiling results of the
category members regarding their ability to bind to proteins and to DNA
(properties which are likely responsible for developmental toxicity) are
similar to those of the target chemical.
Epichlorhydrin if administered to pregnant
rats caused no embryotoxic, foetotoxic or teratogenicity effects (Mark
et al., 1982; John, 1983). No developmental malformations were noted in
mice treated with glycidol in a developmental study (Mark et al., 1982;
IARC Monographs, Volume 77). No influence on embryonic or pup
development was observed in the 13- week repeated dose toxicity and
fertility study conducted with triglycidyl isocyanurate (HPV, No. 201
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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