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EC number: 701-197-2
CAS number: -
The test substance (targert substance
GE-100) was applied to the skin of one group of ten Sprague-Dawles rats(
five males and five females). The application was performed with the
undiluted test substance at the dose of 2000 mg/kg, taking into
consideration that its specific gravity was 1.2 . The test site was then
covered by a semi-occlusive dressing for 24 hours. Clinical signs,
mortality and body weight gain were checked for a period of 14 days
following the single application ofthe test substance. No death occurred
at 2000 mg/kg. No clinical signs were observed during the study. One
female did not gained weight during the first week of the study and
another female lost weight during the second week of the study. The body
weight gain of the other animals was not affected by treatment with the
test substance. No cutaneous reactions were observed. No apparent
abnormalities were observed at necropsy. In conclusion, under the
experimental conditions, the dermal LD50 of the test substance is higher
than 2000 mg/kg in rats.
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