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EC number: 701-197-2
CAS number: -
The prediction was based on dataset comprised from the following descriptors: "Chromosome aberration"Estimation method: Takes highest mode value from the 5 nearest neighboursDomain logical expression: Result: In Domain(("a" and ("b" and ( not "c") ) ) and ("d" and "e" ) ) Domain logical expression index: "a"Referential boundary: The target chemical should be classified as Epoxides by US-EPA New Chemical CategoriesDomain logical expression index: "b"Referential boundary: The target chemical should be classified as Alcohol AND Alkyl halide AND Dihydroxyl group AND Epoxide AND Ether AND Glycerol and derivatives AND Saturated heterocyclic fragment by Organic functional groupsDomain logical expression index: "c"Referential boundary: The target chemical should be classified as Alkane, branched with tertiary carbon OR Alkene OR Allyl OR Aryl OR Carboxamide OR Carboxylic acid OR Carboxylic acid ester OR Conjugated system OR Cycloalkane OR Fused saturated heterocycles by Organic functional groupsDomain logical expression index: "d"Parametric boundary:The target chemical should have a value of log Kow which is >= -1.09 Domain logical expression index: "e"Parametric boundary:The target chemical should have a value of log Kow which is <= 0.628
The target chemical was profiled as
"Epoxides" by the "US EPA New Chemical Categories". Common properties of
epoxides are high reactivity, cytotoxicity, and high probability of
mutagenic potential and/or carcinogenicity. Therefore chemicals with the
same profiling result have been retrieved from the database. The
chemicals containing other chemical elements in their structure and/or
other organic functional groups were considered dissimilar to the target
chemical and have been removed from the domain. The target chemical is
obtained by the reaction of epychlorohydrin with glycerol. Therefore,
epichlorohydrin is considered to be a suitable candidate for
read-across. Glycidol is the simplest representative of glycidyl ethers
category (HPV, Epoxy Resin Systems Task Group (ERSTG), 2001). The other
category members possess epoxy moieties in their structures and their
profiling results regarding the ability to bind to proteins and to DNA
(property which is likely responsible for genetic toxicity) are similar
to those of the target chemical. Therefore, they considered to be
suitable for read-across. The target substance was predicted to be
positive in in vivo Micronucleus Test.
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