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EC number: 701-197-2
CAS number: -
The effect of multiple dermal application of
EPON 562 was studied in Albino rabbits (Hine et al., 1958). Acetone was
used as a negative control solution. These tests were set up according
to the Latin square method: four to five spots on each animal's back
were depilated, and a different compound applied to each. The compounds
was diluted with acetone if it was not practical to apply them
undiluted, and the amounts applied were adjusted to give approximately
the same final quantity of each compound. The materials remained on the
skin for both one-hour and seven-hour periods, in most cases, after
which they were removed with acetone. Readings were made just prior to
application. The degree of irritation was scored directly after the test
material removal. The irritation reactions were scored according to the
method of Draize (the maximum score for erythema and edema is 8).
Applications were made daily except week ends for a total of 20 days, or
until death or eschar formation made further application impractical.
The rabbits were weighed weekly, and after the final application,
representative animals were killed to determine the systemic effects.
Suitable tissues were taken for histologic study. Repeated application
of EPON 562 caused definite signs of skin irritation. The applications
which were left in place for seven hours did not produce a significantly
greater score than the one-hour applications. Final mean scores with
EPON 562 approached the maximum degree of irritation (7.6). In the group
of animals that were exposed during 8 day to the test material, two of
the four treated animlas died six days after the eighth (last)
application. These animals showed dyspnea, rales, and nasal discharge,
and signs of bronchopneumonia were found in all at necropsy. According
to the authors, the death of these animlas was primarily due to
disability produced by the extreme irritation, rather than to any
systemic effect of the resin.
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