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Toxicological information

Developmental toxicity / teratogenicity

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Administrative data

Endpoint:
developmental toxicity
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Adopted according to OECD SIDS, peer reviewed data

Data source

Referenceopen allclose all

Title:
No information
Author:
IRDC (International Research and Developmental Corporation): Modified teratology study in rats with o-Nitrochlorobenzene, Report no. ML-82-090A, october 1984 (at the request of Monsanto Company), EPA-OTS0522332
Bibliographic source:
(as cited in OECD SIDS)
Reference Type:
secondary source
Title:
1-Chloro-2-nitrobenzene CAS: 88-73-3, SIDS Initial Assessment Report
Author:
OECD
Year:
2001
Bibliographic source:
UNEP publications

Materials and methods

Principles of method if other than guideline:
25 females/group, only one dose
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 1-chloro-2-nitrobenzene
- Analytical purity: commercial

Test animals

Species:
rat
Strain:
Sprague-Dawley

Administration / exposure

Route of administration:
oral: gavage
Duration of treatment / exposure:
d6-d15
Frequency of treatment:
daily
Doses / concentrations
Remarks:
Doses / Concentrations:
0, 100 mg/kg bw in corn oil
Basis:

Control animals:
yes, concurrent vehicle
Details on study design:
Sex: female

Results and discussion

Results: maternal animals

Effect levels (maternal animals)

Dose descriptor:
other: NOAEL developmental toxicity
Effect level:
ca. 100 mg/kg bw/day

Results (fetuses)

Fetal abnormalities

Abnormalities:
not specified

Overall developmental toxicity

Developmental effects observed:
not specified

Any other information on results incl. tables

d6-10: slight maternal body weight loss accompanied  by
reduction in food consumption for d6-16, maternal
reproductive parameters were not affected, fetal body weight
comparable to the respective controls; no teratogenic
effects were observed

Applicant's summary and conclusion