Registration Dossier

Administrative data

Endpoint:
dermal absorption
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: migrated IUCLID4 data set

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
The Toxicologist 11(1), 290 (1991)|(abstr.)
Author:
Mongan, A. et al.
Year:
1991
Reference Type:
publication
Title:
Drug Metabolism and Disposition 20, 436-439
Author:
Nomeir, A.A. et al.
Year:
1992

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat

Results and discussion

Any other information on results incl. tables

After a single non-occlusive, protective dermal application of 14 C-o-chloronitrobenzene at doses of 

ca. 0.65,  6.5 or 65 mg/kg bw to male rats, 

33-40 % of the doses of  o-chloronitrobenzene was absorbed from the skin within 72 h; 

the absorbed 14 C was excreted in urine (21-28 %) and faeces (11-15 %). 

The extent absorption increased with an increase in dose from 0.65 to 6.5 mg/kg bw but increased only neglibly when the 

dose was increased to 65 mg/kg bw.

The extent of urinary excretion of radioactivity was not significantly affected by dose over the range studied. 

The initial rate of urinary excretion was also unaffected by dose. 

The initial rate of faecal exretion increased with dose over the 0.65 to 6.5 mg/kg range, but decreased notably at the high dose.

 

Applicant's summary and conclusion

Conclusions:
33-40 % of the doses of  o-chloronitrobenzene was absorbed from the rat skin within 72 h;