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EC number: 201-854-9
CAS number: 88-73-3
OECD SIDS (2001):
In a first step 50 embryos were tested on hatchability and development
after 4 - 5 days of incubation. In a second step 15 randomly selected
frys from the initial egg cups where observed on their further
development for 33 days. The 33 d-NOEC was determined by the authors
Call & Geiger (1992) to be 0.264 mg/L based on the endpoint 'normal
larvae' related to the hatched larvae. The review of the raw data of the
study shows, that at the next higher test concentration of 0.530 mg/L a
statistically significant effect compared to the control could be
observed, however, there is no dose-effect relation for this endpoint at
higher test concentrations. The highest test concentration of 3.9 mg/L
shows less normal larvae after hatch with a deviation of 7% compared to
the control. Apart from that regarding the endpoint 'normal larvae
related to initial embryos' no effect at any concentration can be seen.
Regarding 'weight' and 'length' of the fry, at both endpoints a
deviation to the control of > 5% can be seen at a concentration of 2.04
mg/L. Also for this endpoint there is no dose-effect relationship seen
at the next higher concentration. As statistically significant effects
for the endpoint "normal larvae" were seen at concentrations above 0.264
mg/L, the NOEC derived by the authors is used for the hazard assessment
for reasons of precaution.
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