Registration Dossier

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: migrated IUCLID4 data set

Data source

Reference
Reference Type:
publication
Title:
No information
Author:
Linch, A.L.
Year:
1974
Bibliographic source:
Am. Ind. Hyg. Assoc. J. 35, 426-432

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

Based on clinical and laboratory evaluation of cyanosis cases during a 10-year period a number of cyanogenic aromatic nitro compounds were ranked in descending order of relative hazard relating to their cyanogenic potential observed in exposed industrial workers (rank 1 = most potent, rank 13 = least potent): 

o-chloronitrobenzene was classified in rank 7; 

laboratory evaluation showed that total oxygenatable haemoglobin in some cases, notably after be expected from methaemoglobin analysis (unspecified route of absorption)

Applicant's summary and conclusion