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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1992
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Adopted according to OECD SIDS, peer reviewed data

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1992
Reference Type:
secondary source
Title:
1-Chloro-2-nitrobenzene CAS: 88-73-3, SIDS Initial Assessment Report
Author:
OECD
Year:
2001
Bibliographic source:
UNEP publications

Materials and methods

Principles of method if other than guideline:
Method: other: 10 male rats/conc., head-only exposure, 6 conc., heated vapour was diluted with humidified and O2-enriched air and thus converted to a mixture of vapour and liquid aerosol, post exposure observation time: 14 d
GLP compliance:
not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 1-chloro-2-nitrobenzene
- Analytical purity: 99.8%

Test animals

Species:
rat
Strain:
other: CD
Sex:
male

Administration / exposure

Route of administration:
other: inhalation: mixture of vapour and liquid aerosol
Duration of exposure:
4 h
No. of animals per sex per dose:
10

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LC50
Effect level:
ca. 3 200 mg/m³ air
Exp. duration:
4 h
Gross pathology:
not reported

Any other information on results incl. tables

value: LD50: 495 ppm

Applicant's summary and conclusion