Registration Dossier

Administrative data

Endpoint:
respiratory sensitisation: in vivo
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1973
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Significant methodological deficiencies no data on purity, study documentation incomplete, no data on GLP

Data source

Reference
Reference Type:
publication
Title:
Experimentelle Untersuchungen der allergenen Wirkung von Ortho- und Paranitrochlorbenzol
Author:
Rusakov, N.V. et al.
Year:
1973
Bibliographic source:
Gig. Sanit. No. 3, 13-16 (1973)

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Rats were exposed via inhalation to o-chloronitrobenzene for 5 months.
Vanier and Praustnitz-Küstner method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Ortho-nitrochlorbenzol
- Analytical purity: no data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Test system

Route of induction exposure:
inhalation
Route of challenge exposure:
other: Vanier and Praustnitz-Küstner method
Vehicle:
other: Vanier and Praustnitz-Küstner method
Concentration:
0, 0,008 mg/m3
No. of animals per dose:
25
Challenge controls:
no data
Positive control substance(s):
none

Results and discussion

Applicant's summary and conclusion

Interpretation of results:
sensitising