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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation
Remarks:
in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1973
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well documented publication/study report which meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973

Materials and methods

Test guideline
Qualifier:
no guideline followed
Deviations:
not applicable
Principles of method if other than guideline:
Method: 3 drops(10% sol.) to the clipped area of the skin; 22nd d inj.of Freund-adjuvans and TS into the hind paw (0.5 mg/kg bw), 28th d 3 drops (10 % sol.) to an untreated clipped area of the skin; reading time not mentioned
GLP compliance:
no
Type of study:
other: modified Freunds complete adjuvant test

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Ortho-nitrochlorbenzol
- Analytical purity: no data

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
other: epicutaneous, no more informations
Vehicle:
other: acetone
Concentration / amount:
10% in acetone
Challengeopen allclose all
Route:
other: epicutaneous, no more informations
Vehicle:
other: acetone
Concentration / amount:
10% in acetone
No. of animals per dose:
10
Details on study design:
1st application: Induction 10 % ; 2nd application: Challenge 10 %
Challenge controls:
no data
Positive control substance(s):
not specified

Study design: in vivo (LLNA)

Statistics:
no data

Results and discussion

Any other information on results incl. tables

No more data given

Applicant's summary and conclusion

Interpretation of results:
sensitising
Remarks:
Migrated information