Registration Dossier

Toxicological information

Basic toxicokinetics

Currently viewing:

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: migrated IUCLID4 data set

Data source

Reference
Reference Type:
publication
Title:
Biochem. J. 64, 38-44
Author:
Bray, H.G. et al.
Year:
1956

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Metabolite characterisation studies

Metabolites identified:
yes

Any other information on results incl. tables

48 h after a single oral administration of 100 mg/kg bw of o-chloronitrobenzene to rabbits, 

0.3 % of the administered dose was found in faeces as unabsorbed material which was completely reduced to the chloroaniline; 

in the urines collected each 24 h for 48 h the following metabolites of o-chloronitrobenzene were detectable (expressed as per-
centages of the administered dose): 

- ether glucuronide (42 %)

- ethereal sulphate (24 %)

- mercapturic acid (7 %)
- free chloroaniline (9 %) 

(total accounted for: 82 %)

Applicant's summary and conclusion