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Toxicological information

Toxicity to reproduction

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Administrative data

Endpoint:
toxicity to reproduction
Remarks:
other: T41-04:
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP - Guideline study

Data source

Referenceopen allclose all

Title:
No information
Author:
Horstman, M.G. et al.: The Toxicologist 11, 87 (1991) (abstr.)
Title:
No information
Author:
NTP, Technical Report Series No. 33, NIH Publication 93-3382, July/1993

Materials and methods

GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 1-chlor-2-nitrobenzene
- Analytical purity: 99 %

Test animals

Species:
rat
Strain:
other: F344/N
Sex:
male/female

Administration / exposure

Route of administration:
inhalation
Duration of treatment / exposure:
Exposure period: 13 w
Frequency of treatment:
6 h/d, 5 d/w
Doses / concentrations
Remarks:
Doses / Concentrations:
0, 4.5, 9 or 18 ppm (approx. 0, 28.8, 57.6, 115.2 mg/m3)
Basis:

No. of animals per sex per dose:
10
Control animals:
yes, concurrent no treatment

Results and discussion

Overall reproductive toxicity

Reproductive effects observed:
not specified

Any other information on results incl. tables

females: no effects observed
males, 18 ppm: decreases in cauda epididymis weights (6.8%),
and in the spermatid count and spermatid heads/testis (ca.
13%)

Applicant's summary and conclusion