Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Dose descriptor:
NOAEL
20 mg/kg bw/day

Repeated dose toxicity: inhalation - systemic effects

Endpoint conclusion
Dose descriptor:
LOAEC
7 mg/m³

Mode of Action Analysis / Human Relevance Framework

Additional information

Repeated dose toxicity: via oral route - systemic effects (target organ) cardiovascular / hematological: other

Repeated dose toxicity: inhalation - systemic effects (target organ) cardiovascular / hematological: other

Justification for classification or non-classification

The LOAEC for effects on red blood cells (MetHb formation) is 7,08 mg/m³ (= 1,1 ppm). This leads to an EU-GHS classification as STOT RE Cat 1. Under DSD T-R48/23 is the appropriate classification based on the available data.