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EC number: 287-476-5
CAS number: 85535-84-8
Number of controls not specified.
The potential of a C10-13 chlorinated
paraffin (assumed to be approximately 50% chlorinated) to produce skin
sensitisation in guinea pigs has been assessed using the Magnusson and
Kligman method (which involves injection of Freund's complete adjuvant,
followed by dermal induction and then dermal challenge with the test
substance). In the study (reported in the final RAR (EU, 2000) as
well-conducted and performed according to modern protocols and using
suitable induction times) animals were challenged with undiluted C10 -13
paraffin (50% chlorinated) and evaluated after 24 hours; 2/20 showed
marked diffuse redness and 1/20 showed slight redness and dryness. When
the same animals were re-challenged 1 week later, no skin reactions were
seen. No skin reactions were seen in the control group.
In conclusion, the paraffin tested did not
induce skin sensitisation in guinea pigs, and no classification or
labelling with respect to skin sensitisation would be required under EU
CLP or DSD regulations.
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