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EC number: 287-476-5
CAS number: 85535-84-8
In a well
reported human occluded patch test study, Cereclor 50 LV and Cereclor 63
L (C10-13 chlorinated paraffins; 50 and 63% chlorination, respectively)
were applied to the skin of the upper arm of 26 healthy volunteers (at
20 µl) for 48 h, with patch test renewal after the first 24 h. The
degree of severity of erythema and dryness reactions were determined by
two independent assessors, 1 h after removal of the patches and residues
at each of the two time points (24 and 48 h).
numerical scores for Cereclor 50 LV (totalled over the two assessment
times) for the two assessors were 1.69 and 0.81 for erythema (on a 12
point scale) and 0.38 and 0.65 for dryness (on a 4 point scale), with
the total score (i.e. erythema plus dryness) being 2.07 and 1.46. Those
for Cereclor 63 L were 1.62 and 1.38 for erythema, 0.42 and 0.73 for
dryness, with a total score of 2.04 and 2.11. The number of severe
reactions (moderate redness, oedema or vesiculation), as adjudged by
either or both assessors at the 48 h assessment, were 1 and 0 for
Cereclor 50 LV and Cereclor 63 L, respectively. No glazing, wrinkling,
translucency or scaling of the skin was reported. The liquid paraffin
control was assigned comparable or higher values than either of the
Cereclor 50 LV and Cereclor 63 L were considered as only mildly irritant
under these test conditions.
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