Alkanes, C10-13, chloro

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Limited reporting, but cited in final RAR (EU, 2000); considered adequate for assessment

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1974

Report date:

1974

Reference 2

Reference Type:

secondary source

Title:

European Union Risk Assessment Report, alkanes C10-13, chloro

Author:

EU

Year:

2000

Bibliographic source:

European Union Risk Assessment Report (RAR), final

Materials and methods

Principles of method if other than guideline:

Acute toxicity of Cereclor 50 HS following single inhalation exposure in rats

GLP compliance:

no

Remarks:

Prior to GLP

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Alkanes, C10-13, chloro

EC Number:

287-476-5

EC Name:

Alkanes, C10-13, chloro

Cas Number:

85535-84-8

IUPAC Name:

Alkanes, C10-C13, Chloro

Details on test material:

- Name of test material (as cited in study report): Cereclor 50HS
- Substance type: technical product
- Physical state: no data
- Analytical purity: no data
- Impurities (identity and concentrations): no data on presence/absence of stabiliser
- Composition of test material, percentage of components: 50% chlorinated, short chain chlorinated paraffin (specific carbon chain length not identified, but C10-13 according to IPCS, 1996)

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

no data

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

not specified

Vehicle:

other: unchanged (no vehicle)

Details on inhalation exposure:

Maximum possible concentration at 150oC

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

1 h

Concentrations:

Not specified, but includes 48.17 g/m3

No. of animals per sex per dose:

no data

Control animals:

not specified

Details on study design:

no data

Statistics:

no data

Results and discussion

Preliminary study:

no data

Effect levels

Sex:

not specified

Dose descriptor:

LC50

Effect level:

> 48 170 mg/m³ air (nominal)

Based on:

test mat.

Exp. duration:

1 h

Remarks on result:

other: No details on sex or CL given.

Mortality:

None reported

Clinical signs:

other: "Slight eye and nose irritation" reported in animals exposed for 1 hour to SCCP vapour. Recovery occurred "soon" after exposure and remained normal throughout the [unspecified] observation period.

Body weight:

No data

Gross pathology:

No data

Other findings:

No data

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

No deaths and only mild signs of eye and nose irritation were seen in rats exposed to the "vapour" of Cereclor 50HS, a short-chain chlorinated paraffin (50% chlorination) at a concentration of 48.17 g/m3 for 1 hour. The acute inhalation LC50 value is therefore greater than 48.17 g/m3 (48.17 mg/L).

Executive summary:

Cereclor 50 HS (a 50% chlorinated, short-chain paraffin - presumably C10-13) was tested for acute inhalation toxicity in rats at a vapour concentration of 48.17 g/m3 for 1 h. No deaths were reported and only slight nose and eye irritation were seen. Recovery occurred "soon" after exposure and remained normal throughout the [unspecified] observation period. The 1 h acute inhalation LC50 for Cereclor 50 HS is greater than 48.17 g/m3 (48.17 mg/L) and this test material would not be classified as acutely toxic by the inhalation route under EU CLP or DSD regulations.