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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Limited reporting, but cited in final RAR (EU, 2000); considered adequate for assessment

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1974
Report Date:
1974
Reference Type:
secondary source
Title:
European Union Risk Assessment Report, alkanes C10-13, chloro
Author:
EU
Year:
2000
Bibliographic source:
European Union Risk Assessment Report (RAR), final

Materials and methods

Principles of method if other than guideline:
Acute toxicity of Cereclor 50 HS following single inhalation exposure in rats
GLP compliance:
no
Remarks:
Prior to GLP
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Cereclor 50HS
- Substance type: technical product
- Physical state: no data
- Analytical purity: no data
- Impurities (identity and concentrations): no data on presence/absence of stabiliser
- Composition of test material, percentage of components: 50% chlorinated, short chain chlorinated paraffin (specific carbon chain length not identified, but C10-13 according to IPCS, 1996)

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
no data

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
Maximum possible concentration at 150oC
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
1 h
Concentrations:
Not specified, but includes 48.17 g/m3
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no data
Statistics:
no data

Results and discussion

Preliminary study:
no data
Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 48 170 mg/m³ air (nominal)
Based on:
test mat.
Exp. duration:
1 h
Remarks on result:
other: No details on sex or CL given.
Mortality:
None reported
Clinical signs:
"Slight eye and nose irritation" reported in animals exposed for 1 hour to SCCP vapour. Recovery occurred "soon" after exposure and remained normal throughout the [unspecified] observation period.
Body weight:
No data
Gross pathology:
No data
Other findings:
No data

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
No deaths and only mild signs of eye and nose irritation were seen in rats exposed to the "vapour" of Cereclor 50HS, a short-chain chlorinated paraffin (50% chlorination) at a concentration of 48.17 g/m3 for 1 hour. The acute inhalation LC50 value is therefore greater than 48.17 g/m3 (48.17 mg/L).
Executive summary:

Cereclor 50 HS (a 50% chlorinated, short-chain paraffin - presumably C10-13) was tested for acute inhalation toxicity in rats at a vapour concentration of 48.17 g/m3 for 1 h. No deaths were reported and only slight nose and eye irritation were seen. Recovery occurred "soon" after exposure and remained normal throughout the [unspecified] observation period. The 1 h acute inhalation LC50 for Cereclor 50 HS is greater than 48.17 g/m3 (48.17 mg/L) and this test material would not be classified as acutely toxic by the inhalation route under EU CLP or DSD regulations.