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EC number: 287-476-5
CAS number: 85535-84-8
The absorption of radioactivity through the
epidermal membranes during the first 7 h continuous skin contact could
not be quantified. An apparent steady state absorption was achieved
during the time period 23-54 h and the rate of absorption during this
time was calculated to be approx. 0.00014% of the applied dose/cm2/h.
The overall mean calculated permeability constant was 0.87 x 10-5 ± 0.09
x 10-5 cm/h, indicating that Cereclor 56L was absorbed very slowly.
The absorption through human epidermal skin
membranes in vitro of Cereclor 56L (a C10-13 chlorinated paraffin; 56%
chlorination) was assessed. Cereclor 56L was mixed with a radiolabelled
analogue (chlorinated [14C-labelled] n-undecane with 58%
chlorination) to facilitate quantitation, and applied in a cutting oil
as an 18.5% (w/w) solution at a dose of 158 µl/cm2 (equivalent to 29.1
mg/cm2). Absorption was determined in a static glass diffusion cell
system at 30 ± 1oC using two
different receptor fluids, stirred continuously and sampled at various
time points over 54 hours. The receptor fluids were VOLPO 20 in saline
or Marlowett in saline.
No absorption was detected over the first 7
hours, however a steady state for absorption was established during the time
period 23 to 54 hours, the absortion rate being similar for both
receptor fluids. The overall mean absorption rate of the chlorinated
paraffin was 0.04 µg/cm2/h over this period, the overall
extent of absorption was less than 0.01% of the applied dose and the
overall mean permeability constant was 0.87 x 10-5 cm/h.
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