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EC number: 287-476-5 | CAS number: 85535-84-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: A well-conducted study, considered adequate for assessment
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Reference Type:
- secondary source
- Title:
- European Union Risk Assessment Report, alkanes C10-13, chloro
- Author:
- EU
- Year:
- 2 000
- Bibliographic source:
- European Union Risk Assessment Report (RAR), final
Materials and methods
- Principles of method if other than guideline:
- A undiluted C10-13 chlorinated paraffin (52% chlorination) was applied to the skin of rats under an occlusive dressing for 24 h and signs of systemic toxicity (and irritation) were assessed for at least 7 days.
- GLP compliance:
- no
- Remarks:
- Prior to GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Alkanes, C10-13, chloro
- EC Number:
- 287-476-5
- EC Name:
- Alkanes, C10-13, chloro
- Cas Number:
- 85535-84-8
- IUPAC Name:
- Alkanes, C10-C13, Chloro
- Details on test material:
- - Name of test material (as cited in study report): C10-13 chlorinated paraffin (52% chlorinated)
- Substance type: technical product
- Physical state: liquid
- Analytical purity: no data
- Impurities (identity and concentrations): no data on presence of stabilisers
- Composition of test material, percentage of components: C10-13 chlorinated paraffin (52% chlorinated)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- No data
- Duration of exposure:
- 24 hours
- Doses:
- 2.5 ml/kg body weight (about 2.8 g/kg bw)
- No. of animals per sex per dose:
- 3
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: at least 7 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no data
- Other examinations performed: signs of systemic toxicity and irritation - Statistics:
- No data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2.5 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No details on sex or CLs given
- Mortality:
- None reported
- Clinical signs:
- other: No signs of systemic toxicity were observed
- Gross pathology:
- No data
- Other findings:
- Slight erythema and slight desquamation were noted on days 3 and 7 after application.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- No deaths or other signs of systemic toxicity were seen in groups of rats given a single dermal application of 2.5 ml/kg bw (about 2.8 g/kg bw) of a C10-13 chlorinated paraffin (52% chlorination) under an occlusive dressing for 24 h. The dermal LD50 is therefore considered to be greater than 2.5 ml/kg bw (2.8 g/kg bw).
- Executive summary:
According to an expert review on SCCPs (EU, 2000), a C10-13 chlorinated paraffin (52% chlorination) was tested for acute dermal toxicity at 2.5 ml/kg bw (about 2.8 g/kg bw) in an well-conducted study. When applied undiluted, under an occlusive dressing, to groups of 3 rats for 24 h, local signs of irritation (slight erythema and slight slight desquamation) were seen at the application site at 3 and 7 days post-application. No deaths or other signs of systemic toxicity were reported in the treated rats. The acute dermal LD50 of this C10-13 chlorinated paraffin is greater than 2.5 ml/kg bw (about 2.8 g/kg bw) and therefore the test material would not be classified for acute dermal toxicity under EU CLP or DSD regulations.
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