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EC number: 287-476-5
CAS number: 85535-84-8
The reproductive toxicity of a C10-12 chlorinated paraffin (58% chlorination) was assessed in a GLP study performed using a protocol similar to OECD Guideline 206, in which Mallard ducks were fed the SCCP in the diet for 22 weeks at a concentration of up to 1000 mg/kg diet. A decrease in 14-day embryo viability was seen at the top dose, but no effects (including egg shell cracking, egg weight, egg shell thickness, and hatchability) were seen at 166 or 28 mg/kg diet. Therefore, the reproduction NOEC is considered to be 166 mg/kg diet and the parental NOEC 1000 mg/kg diet (Shults et al. 1984).
In a reproduction test, performed using a
protocol similar to OECD Guideline 206, and to GLP, groups of 20 pairs
of adult Mallard ducks (Anas platyrhynchos) were fed a C10-13
chlorinated paraffin (58% chlorinated) in the diet at 28, 166 or 1000
mg/kg diet. Treatment duration was 22 weeks, including a 9-week
pre-egg-laying period without photostimulation, a 3-week pre-egg-laying
period with photostimulation and a 10-week egg-laying period with
photostimulation. The young were observed for 14 days (note the young
were not fed with the test substance). Endpoints recorded included adult
mortality, egg production, number of cracked eggs, egg shell thickness,
viability, hatchability and effects on young birds.
No treatment-related effects were seen on
adult mortality, appearance, behaviour, body weight or food consumption.
A decrease in 14-day embryo viability (statisitcally significant at
weeks 3 and 6) and a decrease in egg shell thickness (statistically
significant but still within the normal range) were seen at the highest
concentration only. There were no other treatment-related effects on
reproductive endpoints, including number of eggs laid, number of cracked
eggs, mean egg weight; number of live 21-day embryos, hatchlings or
14-day old survivors; or hatchling appearance, behaviour or body weight.
A decrease in 14-day embryo viability was
seen in a reproduction toxicity test in which Mallard ducks were fed a
C10-13 chlorinated paraffin (58% chlorinated) in the diet for 22 weeks
at a concentration of 1000 mg/kg diet; no effects were seen at 166 or 28
mg/kg diet. Therefore, the reproduction NOEC was 166 mg/kg diet and the
parental NOEC was 1000 mg/kg diet.
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