Registration Dossier
Registration Dossier
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EC number: 939-253-5 | CAS number: 68424-85-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Data waiving:
- exposure considerations
- Justification for data waiving:
- other:
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- appearance / physical state / colour
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From November 21, 2006 to February 19, 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.6303 (Physical State)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.6302 (Color)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.6304 (Odor)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- - Purity 94.4% (LC-MS/MS)
- Physical state at 20°C and 1013 hPa:
- solid
- Key result
- Form:
- solid: crystalline
- Remarks:
- tenacious and sticky
- Colour:
- white
- Odour:
- other: faint, marzipan-like odour
- Substance type:
- organic
- Conclusions:
- Under the study conditions, the substance was a crystalline, hygroscopic, sticky white solid with a faint marzipan-like odour at 20ºC.
- Executive summary:
A study was conducted to determine the appearance, physical state and colour of the test substance according to EPA OPPTS 830.6302, .6303 and .6304, in compliance with GLP. Under the study conditions, the substance was a crystalline, hygroscopic, sticky white solid with a faint marzipan-like odour at 20ºC (Schulze, 2007).
The test substance is hygroscopic
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From March 15, 2012 to March 19, 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7950 (Vapor Pressure)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: by loss of weight or by trapping vaporisate
- Specific details on test material used for the study:
- - Molecular formula: Cn+9 H2n+14 N Cl (n=12-16)
- Molecular weight: 352.5
- Substance type: Solid
- Physical state: White powder with lumps (determined at NOTOX)
- Analytical purity: 99.24 ± 0.676 % w/w
- Method used for analysis: LC-MS/MS and GC-MS (external standard)
- Composition of test material, percentage of components: Refer to the attached background materail for details
- Purity test date: 26 October, 2011
- Lot/batch No.: 667S0002
- Expiration date of the lot/batch: 30 April, 2012
- Stability under test conditions: Stable
- Storage condition of test material: At room temperature in the dark in desiccator
- Study specific test substance information: Freeze dried Arquad sample MCB-50 EP, stored in desiccator above P2O5 and substance was handeled in nitrogen environment in glovebox
- Other:
- Chemical name: Benzyl(C12-C16-alkyl)dimethylazanium chloride - Key result
- Temp.:
- 20 °C
- Vapour pressure:
- 0.002 Pa
- Remarks on result:
- other: The value of vapour pressure is < 0.0015 Pa
- Temp.:
- 20 °C
- Vapour pressure:
- 0 mm Hg
- Remarks on result:
- other: The value of vapour pressure is < 0.000011 mm Hg
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- 0.006 Pa
- Remarks on result:
- other: The value of vapour pressure is < 0.0058 Pa
- Temp.:
- 25 °C
- Vapour pressure:
- 0 mm Hg
- Remarks on result:
- other: The value of vapour pressure is < 0.000043 mm Hg
- Conclusions:
- Under the study conditions, the vapour pressure of test substance was found to be <1.5E-03 Pa at 20°C and <5.8E-03 Pa at 25°C (isothermal thermo gravimetric effusion method).
- Executive summary:
A study was conducted to determine the vapour pressure of the test substance according to OECD Guideline 104, EU Method A.4 and EPA OPPTS 830.7950 (isothermal thermo gravimetric effusion method), in compliance with GLP. Approximately 14.5 or 15.2 mg of the test substance was applied to the surface of a roughened glass plate as a homogeneous layer. The plates were dried at 30°C under nitrogen in the thermogravimetric analyzer (TGA). The weight loss of the test substance was measured continuously as a function of time. Benzo(ghi)perylene, chrysene, hexachlorobenzene, naphthalene and water were used as reference substances for validation. The log Vt, 20 value which was obtained by extrapolation of the evaporation rate curve, fitted in the vapour pressure regression curve. Under the study conditions, the vapour pressure of test substance was found to be <1.5E-03 Pa at 20°C and <5.8E-03 Pa at 25°C (Brekelmans, 2012).
Formulas used:
Evaporation rate: (νT) =Dm/ F x t [g/cm /h]
where:
Dm = weight loss of the test substance [g]
F = surface of the sample plate [cm2]
t = elapsed time for the weight loss [h]
Vapour pressure equation log PT=c lognT+d
where:
c = constant specific for the experimental arrangement
d = constant specific for the experimental arrangement
Vapour pressure regression curve log PT=a 1/T+b
where:
T = temperature [K]
a = slope [K]
b = intercept
Results:
The isothermal TGA effusion method was applied for the determination of the vapour pressure of the test substance is:
The vapour pressure of the test substance at 20°C (293K) and 25°C (298K) was:
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Data source
Materials and methods
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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