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EC number: 939-253-5
CAS number: 68424-85-1
A study was conducted to determine the acute
dermal toxicity of the test substance (purity > 93%) according to a
method similar to EPA OPPTS 870.1200. The experiment was performed in
rabbits. The test substance was applied to twelve male and twelve female
rabbits (4 animals/sex/test group) at dose levels of 3, 4 and 5 mL/kg bw
(single application) on the abraded and intact skin of the back. The
test sites were covered with gauze and each animal was wrapped in a
sleeve after application for a 24 h period. After removal of the
dressing, animals were washed with warm water and dried. The animals
were observed for clinical signs and mortality for 14 d. Body weights
were determined at the start of the experiment and at termination (Day
14). In the study, 1/8, 6/8 and 7/8 animals died at 3, 4 and 5 mL/kg bw,
respectively. Under the test conditions, the acute dermal LD50 of the
test substance was found to be 3.56 mL/kg bw (95% c.i.- 3.01 - 4.20
mL/kg bw). After correcting for purity of the active substance, the LD50
was calculated to be 3412.5 mg/kg bw (Levenstein, 1977).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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