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EC number: 939-253-5
CAS number: 68424-85-1
Dose levels (ml/kg)
Time to mortality
1, 2, 7 & 12 days
2, 3, 4 & 6 days
study was conducted to determine the acute dermal toxicity of the test
substance, C12-16 ADBAC (80% active in water), according to a method
similar to EPA OPPTS 870.1200. The experiment was performed in rabbits.
The test substance was applied to twelve male and twelve female rabbits
(4 animals/sex/test group) at dose levels of 3, 4 and 5 mL/kg bw (single
application) on the abraded and intact skin of the back. The test sites
were covered with gauze and each animal was wrapped in a sleeve after
application for a 24 h period. After removal of the dressing, animals
were washed with warm water and dried. The animals were observed for
clinical signs and mortality for 14 d. Body weights were determined at
the start of the experiment and at termination (Day 14). In the study,
1/8, 6/8 and 7/8 animals died at 3, 4 and 5 mL/kg bw, respectively.
Decreases in bodyweight were observed in all surviving animals in all
erythema and oedema at site of application observed post dosing for all
animals in all groups. In the 3 mL/kg dose group (i.e. surviving
animals), the erythema was followed by thickening of the skin and eschar
formation across the back. Under the conditions of the study, the acute
dermal LD50 of the test substance is considered to be 3.56 mL/kg bw (95%
c.i.- 3.01 - 4.20 mL/kg bw). After correcting for 80% purity of the
active substance, the LD50 is calculated to be 2730 mg a.i./kg bw
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