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Short-term toxicity to fish

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Description of key information

In reliable guideline studies, the 96 hour LC50 for C12-C16 ADBAC in freshwater fish was 0.515 and 0.85 mg a. i. /L in Lepomis macrochirus and Salmo gairdneri, respectively.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
0.515 mg/L

Additional information

A guideline study was conducted to evaluate the acute toxicity of C12-C16 ADBAC to Lepomis macrochirus (Bluegill sunfish) under static conditions. In this study, the nominal test substance concentrations were as follows: 0, 0.180, 0.320, 0.490, 0.560 and 0.750 mg/L, which is equivalent to mean measured test concentrations of 0, 0.1973, 0.3171, 0.4555, 0.515 and 0.638 mg a.i./L. Analytical determination was performed for the test substance. Twenty fish per concentration in two replicates were exposed to each test concentration and control. The test and control solutions were renewed at 24, 48 and 72 hours. Observations of symptoms of toxicity and mortality were made at 24, 48, 72 and 96 hours. The LC50was calculated based on measured concentrations following a binomial method. Based on the results obtained, the 96 hour LC50and NOEC of the test substance were calculated to be 0.515 mg a.i./L (c.i.: 0.456-0.638 mg/L) and 0.456 mg a.i./L respectively, based on corrected mean measured test concentrations (Pate Ho and McIntyre DO, 1991).

A guideline study was performed using 2 batches of five rainbow trout (Salmo gairdneri) per concentration under static conditions. Fish were exposed to different concentrations (i.e., 0, 0.5, 0.7, 1.0, 1.4, 2.0, 3.5 and 10.0 mg a.i./L) of 50% active test substance for 96 hours. No chemical analysis of test concentrations was performed. All concentrations reported were nominal. Apart from the mortality rate, abnormal findings during the exposure period in the swimming behaviour, visible physiological functions as well as in the outward appearance of fish were recorded. The test substance showed a 96 hour LC0value of 1.4 mg/L (equivalent to 0.7 mg a.i./L), LC50value of 1.7 mg/L (equivalent to 0.85 mg a.i./L) and 96 hour LC100value of 3.5 mg/L (equivalent to 1.75 mg a.i./L) (Dommrose AM, 1987).

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