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Short-term toxicity to aquatic invertebrates

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Description of key information

In a reliable guideline study, an acute 48 hour EC50 value of 0.016 mg a.i./L for freshwater invertebrates (Daphnia magna) was obtained.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
0.016 mg/L

Additional information

An acute immobilisation guideline study using Daphnia magna was conducted with the read-across substance C12-C16 ADBAC. Daphnids were exposed in a static test to nominal concentrations of 0, 0.0095, 0.015, 0.024, 0.039, 0.063 and 0.1 mg/L, using two times 10 daphnids per concentration. Analytical determination was performed for the test substance. Analytical control at the end of the exposure demonstrated that concentration levels remained constant throughout the exposure period. However, measured concentrations differed from 62% at 0.015 mg/L, increasing to 97 and 96% for 0.063 and 0.1mg/L. Concentrations for the lower levels could not be analysed, as they were below the detection limit of 7.3 µg/L. Under the conditions of the study, 48 hour EC50of the test substance was 0.016 mg a.i./L and the NOEC was 0.0048 mg a.i./L (Thiébaud HN,1999).

In another guideline study, the acute toxicity of C12-C16 ADBAC to Daphnia magna under static exposure conditions was investigated in groups of twentyDaphnia. The test organisms were exposed for 48 hours to nominal concentrations of 0.007, 0.012, 0.019, 0.031 and 0.052 mg a.i./L. The test media were prepared in Softened Elendt M4 medium from an aqueous stock solution with an initial nominal concentration of 10 mg a.i./L. A control group of Daphnia was placed in softened Elendt M4 medium alone. Analytical determination was performed for the test substance. Observations of theDaphniawere made after approximately 24 and 48 hours. Under the conditions of the study, the 48 hour EC50for the immobilisation ofDaphnia magnawas 0.016 mg a.i./L and the NOEC was 0.012 mg a.i./L (Jenkins CA, 2007).

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