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EC number: 939-253-5
CAS number: 68424-85-1
Modified Draize test:
The priming injections elicited very slight to well defined
erythema, and very slight to slight oedma on all occasions.
- The challenge dose produced a well defined erythema and very
slight oedema in all occasions.
As the challenge doses did not produce any greater reaction
in any animal, it may be concluded that is not a sensitising
agent under the conditions of this experiment.
For result tables, kindly refer to the
attached background material section of the IUCLID.
A study was conducted to determine the skin
sensitisation potential of the test substance, C12 -16 ADBAC (50% active
in water) according to EU Method B.6 (modified Draize test). For the
induction phase, 0.1 mL of 0.1% test substance in water was injected
intradermally into the back of each six guinea pigs. This procedure was
repeated every other day, using a different injection site on each
occasion, until a total of nine injections had been given. Injection
sites were examined 24 h after each injection and scored for erythema
and oedema using the Draize scale. After a two week interval, a single
challenge intradermal injection of the same concentration and volume was
given as for induction. Injection sites were examined 24 h after this
challenge dose as before for erythema and oedema. The effects were
compared to those produced by the priming doses in order to determine
whether sensitisation had been produced. The priming injections elicited
very slight to well defined erythema, and very slight to slight oedema
on all occasions. The challenge dose produced a well-defined erythema
and very slight oedema in all occasions. However, the challenge doses
did not produce any greater reaction in any animal. Under the study
conditions, the test substance was not considered sensitizing to guinea
pig skin (Thomas, 1974).
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