Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 939-253-5
CAS number: 68424-85-1
The n-octanol solubility of the test
substance as the sum of the solubilities of each component was 459 g/L
(determined at 20.3 ± 0.5°C). According to information supplied by the
sponsor, the solubility of the test substance in distilled water was 455
g/L (determined at 20.0°C), the solubility in buffer solutions was 444
g/L (determined at 20.1 ± 0.1°C) and the critical micelle concentration
was 0.81 g/L (determined at 19.7 ± 0.1°C).
Table 1. Pow and Log Pow values of the
Main study - Pow values of the test substance
Based on solubility in distilled water
Based on solubility in buffer solutions
Based on critical micelle concentration
study was conducted to determine
the partition coefficient of the test substance
estimation method according to OECD guideline 107 and EU method A.8, in
compliance with GLP. The
partition coefficient was calculated as the quotient of the n-octanol
solubility and the water solubility. Three aliquots between 1.99
and 2.21 g of test substance were weighed into glass vessels and to each
vessel, 2 mL n-octanol was added. The solutions were stirred at 20.3 ±
0.5°C for 24, 48 or 72 hours. As the blank, 2 mL n-octanol was stirred
for 72 hours. After the stirring period, the n-octanol phases were
two-times centrifuged at 16421g and 20°C for 5 minutes. Volumes of 50 μL
of the n-octanol phases were accurately weighed into volumetric flasks
of 50 mL and the flasks were filled up to the mark with methanol.
Thereafter, the solutions were further diluted to obtain concentrations
within the calibration range. The end solution was 85/15% (v/v)
methanol/mobile phase B. Under the conditions of the study, the
partition coefficient (Pow values) of the test substance was determined
to be 1.01, 1.03 and 567 at 20°C. This corresponds to log Pow values of
0.004, 0.01 and 2.75 based on solubility in water, in buffer solutions
and on critical micelle concentration, respectively (Brekelmans, 2012).
The partition coefficient was determined according to OECD Guideline 107 and EU Method A.8 (octanol/water type) (Brekelmans, 2012)
Pow values: 1.01, 1.03 and 567 at 20°C and
log Pow values: 0.004, 0.01 and 2.75 based on solubility in water, in
buffer solutions and on critical micelle concentration, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again