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EC number: 939-253-5
CAS number: 68424-85-1
study was conducted to determine the inhalation acute inhalation
toxicity of the test substance according to OECD Guideline 403 and US
EPA OPP 81 -3, in compliance with GLP. The experiment was performed in
Sprague-Dawley rats. Four groups of ten rats (five males and five
females) were given a single, 4 h whole body exposure at concentration
levels of 0, 0.17, 0.24 and 0.34 mg/L. The animals were observed for 21
d after exposure and were then culled for gross and histopathological
examination of the lungs. Body weight, food and water intake and lung
weight were also determined. There were no deaths in the control group;
one animal (male) died at 0.17 mg/L, four animals died at 0.24 mg/L (3
males, 1 female), and nine animals died at 0.34 mg/L (5 males, 4
females). Clinical signs of toxicity noted were (partial) closing of the
eyes and exaggerated respiratory movement during exposure in all test
groups, gasping and wetness around the mouth during exposure at 0.34
mg/L. Clinical signs were noted in survivors throughout the 21 day
observation period. Decrease of body weight, reduced weight gain, and
reduced food and water intake was generally seen up to Day 14.
Abnormalities noted at necropsy in survivors were increased relative
lung weight, swollen appearance of the lungs and gas-filled stomach and
intestines. Animals that died showed congestion of the lungs, fluid in
the trachea, and gas-filled stomach. Histopathological lung changes in
survivors generally consisted of focal alveolitis and bronchiolitis;
changes in deceased animals generally consisted of focal alveolar wall
necrosis, diffuse congestion, focal alveolar wall oedema and focal
alveolar wall haemorrhage. Under the study conditions, the 4 h LC50 of
the mixture was calculated to be 0.25 mg/L (0.22 -0.28 mg/L), or based
on 77.3% active substance 0.32 mg QAC/L (Jackson, 1990).
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