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EC number: 939-253-5
CAS number: 68424-85-1
study was conducted to determine the acute oral toxicity of the test
substance, C12-16 ADBAC (50% active in water) according to OECD
Guideline 401, in compliance with GLP. Based on the results of a range
finding study, five male and five female rats per dose group weres
administered the undiluted test substance (50% active) by gavage at dose
levels of 500, 794, 1260 and 2000 mg/kg bw (i.e., equivalent to 250,
397, 630 and 1000 mg a.i./kg bw). Animals were observed 1 and 4 h after
dosing and subsequently once daily for 14 days. Mortality and evidence
of overt toxicity were recorded at each observation. Individual body
weights were recorded on the day of treatment (Day 0), Days 7 and 14,
and at termination. All animals were subjected to gross necropsy
examination for any macroscopic abnormalities. One male treated with
1000 mg a.s./kg was found dead six h after dosing; all other deaths were
noted one to two days after treatment. Surviving animals made expected
bodyweight gains over the study period. Major signs of toxicity observed
in both decedent and surviving animals were hunched posture,
pilo-erection, decreased respiratory rate, diarrhoea, lethargy and
ptosis. Ataxia was noted in animals treated with 397 mg a.s./kg bw and
above. There were no survivors following treatment with 630 and 1000 mg
a.s./kg. All surviving animals were normal three to four days after
of decedents revealed abnormally red lungs, dark livers, haemorrhage and
ulceration of the gastric mucosa and congestion of the small intestines.
Major abnormalities seen at necropsy of animals killed at termination
were white thickened areas of the non-glandular region of the stomach.
Scattered white raised areas were also noted. Under the study
conditions, the LD50 was determined to be 358 mg a.i./kg bw (95% c.i:
247-519 mg a.s/kg bw) in males, 438 mg a.i./kg bw (95% c.i.: 288 – 665
mg a.s./kg bw) in females and 398 mg a.s./kg bw (95% c.i.: 298 – 542 mg
a.s./kg bw) in male and females combined (Jones, 1986).
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