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EC number: 939-253-5
CAS number: 68424-85-1
A study was conducted to determine the skin
irritation / corrosion potential of the test substance according to the
method 'Transport of dangerous goods, special recommendations relating
to Class 8, United Nations handbook, 1977'. In this experiment, 0.5 mL
of a 50% solution of test substance was applied under occlusive dressing
to the skin of 1 rabbit for 3, 30, 60 min and 4 h. The skin was washed
with water upon removal of the dressing. Observations were recorded at
24, 48 and 72 h. A confirmatory study was performed with 3 min or 1 h
applications in 3 rabbits each. In the main study, no dermal reactions
were observed at any of the 6 sites after 3 min application. Moderate
erythema with slight oedema at 4 sites and areas of skin necrosis at the
other 2 sites were observed following 1 h application (Primary
irritation index PII: 3 min: 0; 60 min: 4.5). Under the conditions of
the study, the test substance solution was considered to be corrosive to
rabbit skin (Liggit, 1982).
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