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EC number: 939-253-5
CAS number: 68424-85-1
A study was conducted to determine the in
vivo toxicity of the test substance according to OECD Guideline 474, in
compliance with GLP. This study was performed to evaluate the
chromosome-damaging effect of the test substance in mice. The
experimental animals were 50 NMRI mice, divided into 5 groups. Of the 5
groups, three were test groups, one negative control group and one
positive control group. The test groups were treated with 400 mg test
substance/kg bw, the negative control group with distilled water and the
positive control group with 30 mg cyclophosphamide/kg bw. The mice were
killed 24, 48 and 72 h, respectively after treatment. From bone marrow
smears micronucleus counts were made per 1000 polychromatic
erythrocytes. Under the test conditions, the test substance did not
induce an increase in the frequency of micronucleated polychromatic
erythrocytes in peripheral blood samples from both male and female mice
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