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EC number: 939-253-5
CAS number: 68424-85-1
A study was conducted to determine the in
vivo toxicity of the test substance, C12-16 ADBAC (80.2% active in
ethanol) according to OECD Guideline 474, in compliance with GLP. This
study was performed to evaluate the chromosome-damaging effect of the
test substance in mice. The experimental animals were 50 NMRI mice,
divided into 5 groups. Of the 5 groups, three were test groups, one
negative control group and one positive control group. The test groups
were treated with 400 mg test substance/kg bw, the negative control
group with distilled water and the positive control group with 30 mg
cyclophosphamide/kg bw. The mice were killed 24, 48 and 72 h,
respectively after treatment. From bone marrow smears micronucleus
counts were made per 1000 polychromatic erythrocytes. Under the test
conditions, the test substance did not induce an increase in the
frequency of micronucleated polychromatic erythrocytes in peripheral
blood samples from both male and female mice (Kallesen, 1985).
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