Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 939-253-5
CAS number: 68424-85-1
A study was conducted to determine the in
vivo toxicity of the test substance according to OECD Guideline 474, in
compliance with GLP. This study was performed to evaluate the
chromosome-damaging effect of the test substance in mice. The
experimental animals were 50 NMRI mice, divided into 5 groups. Of the 5
groups, three were test groups, one negative control group and one
positive control group. The test groups were treated with 400 mg test
substance/kg bw, the negative control group with distilled water and the
positive control group with 30 mg cyclophosphamide/kg bw. The mice were
killed 24, 48 and 72 h, respectively after treatment. From bone marrow
smears micronucleus counts were made per 1000 polychromatic
erythrocytes. Under the test conditions, the test substance did not
induce an increase in the frequency of micronucleated polychromatic
erythrocytes in peripheral blood samples from both male and female mice
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again