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EC number: 939-253-5
CAS number: 68424-85-1
Table1: Surface tension of 1 g/L aqueous
solution of test substance
Measurement time (s)*
Surface tension [mN/m]
Temperature [deg C]
Table 2: Surface tension of test substance
at different concentrations
The plot of log10[concentration
(g/L)] versus surface tension (mN/m) can be found under Illustration
section of the IUCLID' :
The CMC of an aqueous solution of the test
substance was interpolated to be 0.5 g/L.
critical micelle concentration (CMC) is an important characteristic of a
surfactant. At low concentrations of surfactant, the surface tension of
water is only slightly affected. Increasing
the concentration but before reaching the CMC, the surface tension
changes significantly; After reaching the CMC and above, the surface
tension remains relatively constant or changes with a much more gradual
the CMC, a surfactant is considered to be thermodynamically soluble in
the water; whereas above the CMC, the solubility of a surfactant in
water has been exceeded and the excess surfactant aggregates to form
micelles. These micelles have significantly less effect on the surface
tension of a solution and are considered not to be in solution. Thus,
the water solubility of a surfactant may be expressed in terms of the
A study was conducted to determined the
water solubility of the test substance, C12 -16 ADBAC (94.4% active)
based on critical micelle concentration (CMC), according to OECD
Guideline 115 and EU Method A.5, in compliance with GLP. The CMC were
determined to be 0.50 g/L for C14-chain length and 1.0 g/L for C12
-chain length. Due to the surface activity of the test substance, the
CMC value was considered as a water soluibility equivalent in accordance
with the ECHA R.7a Guidance. Under the study conditions, the CMC of the
test substance was determined to be 500 -1000
mg/L at 20.0 ± 0.5°C (Schulze, 2007).
Bi-distilled water: 455000 mg/L (pH around 5.0)
Buffer solution pH 4: 444000 mg/L (pH: 3.81-3.98)
Buffer solution pH 7: 444000 mg/L (pH: 6.70-6.80)
Buffer solution pH 9: 444000 mg/L (pH: 8.11-8.30)
A study was conducted to determine the water
solubility of the test substance, C12-16 ADBAC (purity: 94.4%) according
to OECD Guideline 105, in compliance with GLP. In this experiment,
the solubility of the test substance
was determined using a modified flask method at 10, 20 and 30°C with a
preincubation at 35°C. 2.0 g of the test substance was
soluble in 4.5 mL of buffer solutions (pH 4, 7 and 9) and 4.4 mL of
bi-distilled water, respectively. Under the study conditions, the water
solubility of the test substance was determined to be 455000 mg/L in
bi-distilled water and 444000 mg/L in buffer solutions and was
independent of the temperature and pH (Schulze, 2007).
The water solubility was determined using the modified flask method according to OECD Guideline 105 as well as based on the critical micelle concentration (CMC) method according to OECD Guideline 115 (Schulze, 2007)
CMC: 810 mg/L at 19.7 °C determined in
partition coefficient study and 500 -1000 mg/L determined in surface
tension study at 20 °C; water solubility = 455000 mg/L in bi-distilled
water and 444000 mg/L in buffer solutions (independent of the
temperature and pH)
to the surface activity of the test substance, the CMC value has been
considered as the pragmatic alternative for water solubility in
accordance with the ECHA R.7a Guidance (ECHA, 2017).
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