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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1975
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report Date:
1975

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Remarks:
predates GLP
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Hexyl salicylate

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data
Doses:
5 g/kg
No. of animals per sex per dose:
10 animals/dose
Control animals:
not specified
Details on study design:
No data
Statistics:
Not required

Results and discussion

Preliminary study:
Not relevant
Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
1/10 rats died
Clinical signs:
Urinary incontinence was observed at 24 hours
Body weight:
No data
Gross pathology:
No data
Other findings:
No data

Any other information on results incl. tables

No additional information

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The acute oral LD50 in rats was greater than 5000 mg/kg bw
Executive summary:

The acute oral LD50 of hexyl salicylate in rats was found to greater than 5000 mg/kg bw, under the conditions of this study. One of 10 rats died; signs of toxicity were imited to urinary incontinence at 24 hours after dosing.