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Short-term toxicity to aquatic invertebrates

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Description of key information

The purpose of this study was to evaluate the acute toxicity of hexyl salicylate to Daphnia magna in a 48 hour, semi-static study with renewal of the test media after 24 hours. This study was carried out to OECD Guideline 202. Nominal exposure concentrations were 0 (control), 0 (solvent control), 0.05, 0.1, 0.23, 0.5 and 1.0 mg/L, the corresponding mean measured concentrations were 0.03, 0.072, 0.140, 0.310 and 0.726 mg/L.  The results of the study are based on the mean measured exposure concentrations.
The 48 hour EC50 was calculated to be 0.357 mg/L (with 95% confidence limits of 0.228 to 0.871 mg/L), the corresponding no-observed effect concentration was 0.140 mg/L.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
0.357 mg/L

Additional information

The purpose of this study (Pavic and Wydra, 2008), was to evaluate the influence of the test item N-hexylsalicylate on the immobilisation of Daphnia magna. The 48-hour EC50 value was 0.357 mg test item/L.

Based on the results of the acute toxicity to Daphnia study, Hexyl salicylate is classified as N Dangerous for the environment with the risk phrase 'R50- very toxic to aquatic organisms' according to Directive 67/548/EEC.

Hexyl salicylate is classified as an acute category 1 with the signal word 'Warning' and the hazard statement 'H400 Very toxic to aquatic life' in accordance with Regulation (EC) No. 1272/2008.