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EC number: 228-408-6
CAS number: 6259-76-3
table 1: mouse mating performance
% females (pregnancies/ matings)
N (females mated twice
table 2: mean litter size - birth
not killed at birth
alive 5 days
weaned 21 days
table 3: reproduction performance
A two-generation study similar to OECD guideline 416 was conducted by
Abbott and Harrisson (1978), on methylsalicylate using 25 F0
mice/sex/dose and 30 F1 mice/sex/dose. The F0 mice were fed MeS at
dietary concentrations of 0.25 or 5% (equivalent to 357 or 714 mg/kg
body weight) from 30 days before the first mating and throughout the
entire study period. F0 and F1 mice were each mated twice. Reproduction
parameters (total born, live born, live at 5 days and at weaning) and
pup abnormalities were monitored. No effects on any parameter were
reported at either dose level. Therefore, the NOAEL (all endpoints) was
714 mg/kg bw/day, the highest dose tested in the study.
Due to the similarity in the backbone of the
molecule between methyl and hexyl salicylate and the similarity of the
metabolite, salicylic acid, it is considered appropriate to use data of
methyl salicylate for hexyl salicylate for reproductive toxicity. The
corresponding alcohol of hexyl salicylate is expected to be less toxic
compared to salicylic acid (Belsito et al., 2007).
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