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EC number: 228-408-6
CAS number: 6259-76-3
A rat acute oral toxicity study and a rabbit acute dermal toxicity study
are available. The older, proprietary studies were also published in a
review of available toxicological data relating to several salicylates
used as fragrance ingredients.
No additional information
The acute oral LD50 of hexyl salicylate in rats was found to greater
than 5000 mg/kg bw, under the conditions of this study. One of 10 rats
died; signs of toxicity were imited to urinary incontinence at 24 hours
No additional results
The dermal LD50 of hexyl salicylate in rabbits was found to be greater
than 5000 mg/kg bw under the conditions of this study. No deaths
occurred and there were no signs of toxicity. Local irritation was
observed at the application site.
Moreno (1975) reports an acute oral LD50 of 5000 mg/kg bw for hexyl
salicylate in the rat; this value is also reported in a published review
Moreno (1975) reports an acute dermal LD50 of 5000 mg/kg bw for hexyl
salicylate in the rabbit; this value is also reported in a published
review (Belsito, 2007).
Hexyl salicylate is of low acute oral and dermal toxicity; acute
inhalation toxicity are not available. Based on the available data,
classification for acute toxicity according to Regulation (EC) No
1272/2008 is not required.
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