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EC number: 228-408-6
CAS number: 6259-76-3
The results are expressed as DPM per lymph node for each group:
0 (vehicle only): 4737DPM
1% w/v: 47194 DPM
2.5% w/v: 36531 DPM
5% w/v: 69591 DPM
10% w/v: 65268 DPM
25% w/v: 109201 DPM
Repeat Test 0 (vehicle only): 5464
0.05% w/v: 10227DPM
0.25% w/v: 19466 DPM
0.5% w/v: 30613 DPM
1% w/v: 59186DPM
2.5% w/v: 59015 DPM
Hexyl salicylate was assessed for skin sensitisation potential using the
mouse LLNA. The assay determined the level of T lymphocyte proliferation
in the lymph nodes draining the site of chemical application, by
measuring the amount of radiolabelled thymidine incorporated into the
dividing cells. Hexyl salicylate in 1:3 Ethanol:DEP was a skin
sensitiser under the conditions of the test with an EC3 value of 0.18%
According to Regulation (EC) No. 1272/2008, a classification of Category
1A skin sensitiser is warranted with the signal word warning and the
hazard statement H317: May cause an allergic skin reaction.
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