Registration Dossier
Registration Dossier
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EC number: 228-408-6 | CAS number: 6259-76-3
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- other: Literature review
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- A toxicologic and dermatologic assessment of salicylates when used as fragrance ingredients
- Author:
- Belsito D, Bickers D, Bruze M, Calow P, Greim H, Hanifin J, Rogers A, Saurat J, Sipes I & Tagami H
- Year:
- 2 007
- Bibliographic source:
- Food and Chemical Toxicology Volume 45, Issue 1, Supplement 1,2007, Pages S318-S361
- Report date:
- 2007
Materials and methods
- Type of sensitisation studied:
- skin
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Literature review
- GLP compliance:
- no
Test material
- Reference substance name:
- Hexyl salicylate
- EC Number:
- 228-408-6
- EC Name:
- Hexyl salicylate
- Cas Number:
- 6259-76-3
- Molecular formula:
- C13H18O3
- IUPAC Name:
- hexyl salicylate
- Details on test material:
- - Name of test material (as cited in study report): Hexyl salicylate
- Analytical purity: One sample was 50% solution in DEP and the other was 100% pure
Constituent 1
Method
- Type of population:
- general
- Ethical approval:
- not specified
Results and discussion
Applicant's summary and conclusion
- Executive summary:
A review of dermal sensitisation of Hexyl Salicylate was conducted. Cross sensitization reactions in humans who were induced with 30% hexyl salicylate and challenged with 15% benzyl salicylate (both substances dissolved in 3: 1 DEP:ethanol) have reportedly been observed.
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