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Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
other: Literature review
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
review article or handbook
Title:
A toxicologic and dermatologic assessment of salicylates when used as fragrance ingredients
Author:
Belsito D, Bickers D, Bruze M, Calow P, Greim H, Hanifin J, Rogers A, Saurat J, Sipes I & Tagami H
Year:
2007
Bibliographic source:
Food and Chemical Toxicology Volume 45, Issue 1, Supplement 1,2007, Pages S318-S361
Report Date:
2007

Materials and methods

Type of sensitisation studied:
skin
Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Literature review
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Hexyl salicylate
- Analytical purity: One sample was 50% solution in DEP and the other was 100% pure

Method

Type of population:
general
Ethical approval:
not specified

Results and discussion

Applicant's summary and conclusion

Executive summary:

A review of dermal sensitisation of Hexyl Salicylate was conducted. Cross sensitization reactions in humans who were induced with 30% hexyl salicylate and challenged with 15% benzyl salicylate (both substances dissolved in 3: 1 DEP:ethanol) have reportedly been observed.