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EC number: 228-408-6
CAS number: 6259-76-3
No additional information
In the study conducted by Drake et al (1974), the
test substance, isoamyl salicylate, was examined for its ability to
induce toxicity following repeated exposure for a period of 13 weeks.
The test substance was administered to male and female Wistar rats via
oral administration in the diet at 4 dose levels, specifically, 0, 50,
500 and 5000ppm. Observations included mortality, food and water
consumption, body weight and body weight gain, haematology, urinalysis,
histopathological examinations and an examination of organ weights.
One mortality was observed in the top dose level of
5000ppm. There was a decrease in weight gain at the highest dietary
level accompanied by a reduced food intake, but a paired-feeding study
showed that this was due to the diet’s unpalatability. The females given
the highest dietary level drank more water than the controls and
produced slightly greater volumes of more dilute urine. The relative
kidney weight was increased in rats on the 500 and 5000 ppm levels
without any histopathological changes. It is concluded that isoamyl
salicylate was exerting a mildly nephrotoxic effect. The relative liver
weight was increased at the highest level of feeding but there were no
other effects attributable to treatment.
Under the conditions of this study, the no observed
adverse effect level (NOAEL) was 500 ppm in diet or circa 50 mg/kg
bw/day. Based on these results, the test substance should not be
classified according to Regulation EC No. 1272/2008. According to
Directive 67/548/EEC, the test substance does not require classification.
Due to the similar structural, physical and chemical
properties of Isoamyl Salicylate, it was considered appropriate for the
purposes of read-across to Hexyl Salicylate
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