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EC number: 228-408-6
CAS number: 6259-76-3
No additional information
The genetic toxicity of 2 -ethylhexyl salicylate was investigated in a
mouse bone marrow micronucleus assay. Groups of five male and five
female mice were treated by single oral administration of 2 -ethylhexyl
salicylate (in arachis oil) at the limit dose level of 2000 mg/kg bw.
The animals were sacrificed and bone marrow smears were prepared at 24,
48 and 72 hours after treatment. A positive (DMBA) and negative
(vehicle) control group were also tested. At least 1000 polychromatic
erythrocytes (PCEs) from each animal were scored for the incidence of
micronuclei. The number of micronucleated normochromatic erythrocytes
(NCEs) was also recorded, and the PCE:NCE ratio determined for each
animal by counting a total of 1000 erythrocytes. No evidence of
micronucleus formation was seen under the conditions of this assay.
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