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EC number: 228-408-6
CAS number: 6259-76-3
No additional results.
In a study conducted by Pitterman (1996), the test
substance, cyclohexylsalicylate, was examined for its ability to induce
embryotoxic and teratogenic effects when administered to pregnant rats
via oral gavage once daily from day 6 to day 15 post coitum. Four test
groups were examined, with concentrations including 0 (control), 40, 120
and 360 mg/kg body weight/day. Each test group contained 24 rats.
Clinical condition and reaction to treatment were
recorded at least once daily. Body weight was recorded on days 0, 6, 16
and 20 of gestation.
All surviving females were sacrificed on day 20 of
gestation and the foetuses removed by caesarean section. Necropsy was
performed and macroscopic examinations of the females conducted. Live
foetuses were weighed, sexed and examined for visceral and skeletal
There were no mortalities observed at any dose level.
No compound related symptoms were observed in any
treatment group. Maternal weight gain was not affected by any treatment
and no treatment related abnormalities were noted at necropsy. All
females had viable foetuses. No treatment related foetal abnormalities
were observed at necropsy and there were no effects on reproductive
The results of this study indicated that repeated oral
administration of cyclohexylsalicylate to pregnant rats did not result
in any signs of cumulative toxicity or any teratogenic or embryotoxic
potential when tested to a dose level of 360 mg/kg body weight/day.
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